News

News

分类出来

Nobel Prize in Chemistry 2018: Directed evolution of enzymes and phage display technology for peptides and antibodies

  • Categories:Industry news
  • Author:
  • Origin:
  • Time of issue:2018-10-02
  • Views:7

(Summary description)In October, the 2018 Nobel Prize in Chemistry was announced. This year's winners are American scientist Frances H. Arnoid, George P. Smith, and British scientist Sir Gregory P. Winter. Their award was based on the results of directed evolution of enzymes and phage display technology for peptides and antibodies.

Nobel Prize in Chemistry 2018: Directed evolution of enzymes and phage display technology for peptides and antibodies

(Summary description)In October, the 2018 Nobel Prize in Chemistry was announced. This year's winners are American scientist Frances H. Arnoid, George P. Smith, and British scientist Sir Gregory P. Winter. Their award was based on the results of directed evolution of enzymes and phage display technology for peptides and antibodies.

  • Categories:Industry news
  • Author:
  • Origin:
  • Time of issue:2018-10-02
  • Views:7
Information
In October, the 2018 Nobel Prize in Chemistry was announced. This year's winners are American scientist Frances H. Arnoid, George P. Smith, and British scientist Sir Gregory P. Winter. Their award was based on the results of directed evolution of enzymes and phage display technology for peptides and antibodies.
Frances H. Arnoid has carried out the first directed evolution of enzymes since 1993, a protein that catalyzes chemical reactions. Her method is often used to develop new catalysts, and the enzymes produced by this method include the development of more environmentally friendly chemicals, pharmaceuticals and the production of more environmentally friendly renewable fuels for the transportation sector.
Prion enzymes are proteins or RNAs produced by living cells that have high specificity and high catalytic efficiency for their substrates, and are therefore an important class of biocatalysts. In 1993, Arnoid completed the first directed evolution experiment of enzymes, which was the first time to implement her theory. Since then, she has continuously improved this method, and now it can be used to develop new catalysts. Based on Arnoid's research results, the industry can manufacture chemicals in more environmentally friendly ways, such as the production of pharmaceuticals and renewable energy.
The other two winners--George P. Smith and Sir Gregory P. Winter--have developed phage display methods to perform directed evolution of antibodies to produce new drugs. The first adalimumab based on this method was approved in 2002 for the treatment of rheumatoid arthritis, psoriasis and inflammatory bowel disease. Since then, phage display has produced antibodies that can neutralize toxins, fight autoimmune diseases, and metastatic cancer.
In 1985, Smith developed a technique called "phage presentation", which is based on a phage virus that specifically infects bacteria. The viruses themselves are nothing more than protein capsules enclosing genetic material. By introducing genes into phages, Smith can evolve novel proteins in phages. Winter used phage display technology to make drug antibodies. Antibodies are tag molecules that our immune cells use to identify other cells.
According to the Royal Swedish Academy of Sciences, "We are in the early stages of the direct evolutionary revolution, which brings the greatest benefit to humanity in many different ways."

Scan the QR code to read on your phone

这是描述信息

Nanjing Purite Biotechnology Co., Ltd. 

Location: 3rd Floor, Building 6, 123 Houjiao Road, Jiangning District, Nanjing, China

Telephone:+86-025-52715975
           17749585716

E-mail:sales@predicte.cn

Contact: Mr. Liu Zhibin

这是描述信息

Copyright  2019  Nanjing Purite Biotechnology Co., Ltd.    www.300.cn    苏ICP备15006463号-1